Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy

Aristolochic acid, an herbal carcinogen, sold on the Web after FDA alert.

to the editor: In 2001, the Food and Drug Administration (FDA) issued warnings and an import alert that herbal products are unsafe if they contain or are suspected to contain aristolochic acid.1 A report in the Journal in 2000 described a cohort of 105 patients in whom rapidly progressive nephropathy developed after they had been given an herbal weight-loss product containing aristolochic acid ...

Human and Experimental Features of Aristolochic Acid Nephropathy (aan; Formerly Chinese Herbs Nephropathy - Chn): Are They Relevant to Balkan Endemic Nephropathy (ben)?

Chinese herbs nephropathy, a rapidly progressive interstitial nephropathy, has been reported in young Belgian women given a slimming regimen including Chinese herbs. It is characterized by early, severe anemia, mild tubular proteinuria, and normal arterial blood pressure. Renal histology shows an extensive, remarkably aor hypocellular interstitial fibrosis associated with tubular atrophy and gl...

DEPRESSION OF THE EXOGENOUS CREATININE/INULIN OR THIOSULFATE CLEARANCE RATIOS IN MAN BY DIODRAST AND p-AMINOHIPPURIC ACID.

Peritubular interaction of unconjugated bilirubin in isolated perfused rat kidney.

1. The interaction of unconjugated bilirubin with peritubular cell membranes of the rat kidney was studied by means of an isolated rat-kidney preparation applying the multiple-indicator-dilution technique. 2. Inulin was used as an extracellular marker and p-aminohippuric acid as a model of organic anion that interacts with the peritubular membrane. 3. A single renal artery injection of a mixtur...

Role of exposure analysis in solving the mystery of Balkan endemic nephropathy.

We evaluated the role of exposure analysis in assessing whether ochratoxin A or aristolochic acid are the agents responsible for causing Balkan endemic nephropathy. We constructed a framework for exposure analysis using the lessons learned from the study of endemic goiter within the context of an accepted general model. We used this framework to develop an exposure analysis model for Balkan end...